Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation.

@article{Rehberg2002Sox10IA,
  title={Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation.},
  author={Stephan Rehberg and Peter Lischka and G. C. Glaser and Thomas Stamminger and Michael Wegner and Olaf Rosorius},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 16},
  pages={5826-34}
}
Sox10 belongs to a family of transcription regulators characterized by a DNA-binding domain known as the HMG box. It plays fundamental roles in neural crest development, peripheral gliogenesis, and terminal differentiation of oligodendrocytes. In accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that Sox10 is an active nucleocytoplasmic shuttle protein, competent of both… CONTINUE READING

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