Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.

@article{Wetering1993Sox4AS,
  title={Sox-4, an Sry-like HMG box protein, is a transcriptional activator in lymphocytes.},
  author={Marc van de Wetering and Mari{\"e}tte Oosterwegel and Klaske van Norren and Hans Clevers},
  journal={The EMBO journal},
  year={1993},
  volume={12 10},
  pages={3847-54}
}
Previous studies in lymphocytes have described two DNA-binding HMG box proteins, TCF-1 and LEF-1, with affinity for the A/TA/TCAAAG motif found in several T cell-specific enhancers. Evaluation of cotransfection experiments in non-T cells and the observed inactivity of an AACAAAG concatamer in the TCF-1/LEF-1-expressing T cell line BW5147, led us to conclude that these two proteins did not mediate the observed enhancer effect. We therefore searched for additional HMG box proteins. By a PCR-aided… CONTINUE READING

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