Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.

@article{Donnelly2005SourcesOF,
  title={Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease.},
  author={Kerry L Donnelly and Coleman I. Smith and Sarah Jane Schwarzenberg and Jos{\'e} Jessurun and Mark D Boldt and Elizabeth J Parks},
  journal={The Journal of clinical investigation},
  year={2005},
  volume={115 5},
  pages={1343-51}
}
Nonalcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess liver triacylglycerol (TAG), inflammation, and liver damage. The goal of the present study was to directly quantify the biological sources of hepatic and plasma lipoprotein TAG in NAFLD. Patients (5 male and 4 female; 44 +/- 10 years of age) scheduled for a medically indicated liver biopsy were infused with and orally fed stable isotopes for 4 days to label and track serum nonesterified fatty acids (NEFAs… CONTINUE READING
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