Sources of estrogen and their importance

  title={Sources of estrogen and their importance},
  author={E. Simpson},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  • E. Simpson
  • Published 2003
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
  • In premenopausal women, the ovaries are the principle source of estradiol, which functions as a circulating hormone to act on distal target tissues. However, in postmenopausal women when the ovaries cease to produce estrogen, and in men, this is no longer the case, because estradiol is no longer solely an endocrine factor. Instead, it is produced in a number of extragonadal sites and acts locally at these sites as a paracrine or even intracrine factor. These sites include the mesenchymal cells… CONTINUE READING
    738 Citations

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