Sources of estrogen and their importance

@article{Simpson2003SourcesOE,
  title={Sources of estrogen and their importance},
  author={E. Simpson},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2003},
  volume={86},
  pages={225-230}
}
  • E. Simpson
  • Published 2003
  • Medicine, Biology
  • The Journal of Steroid Biochemistry and Molecular Biology
In premenopausal women, the ovaries are the principle source of estradiol, which functions as a circulating hormone to act on distal target tissues. However, in postmenopausal women when the ovaries cease to produce estrogen, and in men, this is no longer the case, because estradiol is no longer solely an endocrine factor. Instead, it is produced in a number of extragonadal sites and acts locally at these sites as a paracrine or even intracrine factor. These sites include the mesenchymal cells… Expand
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References

SHOWING 1-10 OF 55 REFERENCES
Aromatase--a brief overview.
TLDR
In principle, it should be possible to develop selective aromatase modulators (SAMs) that block aromat enzyme expression in breast, but allow unimpaired estrogen synthesis in other tissues such as bone. Expand
Minireview: Aromatase and the Regulation of Estrogen Biosynthesis-Some New Perspectives.
TLDR
In postmenopausal women, as in men, estrogen is no longer solely an endocrine factor, but instead is produced in a number of extragonadal sites and acts locally at these sites in a paracrine and intracrine fashion. Expand
The Role of Local Estrogen Biosynthesis in Males and Females
TLDR
Natural (human) and experimental models of estrogen insufficiency have revealed hitherto unexpected roles for estrogens in both males and females, and the potential clinical significance of these findings in terms of the development of new therapeutic modalities is discussed. Expand
DHEA and the Intracrine Formation of Androgens and Estrogens in Peripheral Target Tissues: Its Role during Aging
TLDR
The inhibitory effect of DHEA on the growth of human breast cancer xenografts in vivo in nude mice supports the beneficial use of D HEA as hormone replacement therapy in women. Expand
Aromatase in Human Bone Tissue
  • H. Sasano, M. Uzuki, +4 authors N. Harada
  • Biology, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1997
TLDR
It is demonstrated that aromatase is expressed widely in human bone tissue and may play important roles in maintenance of human bone tissues. Expand
Aromatase expression of human osteoblast-like cells
TLDR
The results suggest that bone is an extraglandular source of local estrogen which plays an important role in bone mineral metabolism through autocrine and paracrine actions. Expand
Concentrations of estrone, estradiol, and estrone sulfate and evaluation of sulfatase and aromatase activities in pre- and postmenopausal breast cancer patients.
TLDR
It is concluded that despite the low levels of circulating estrogens in postmenopausal patients, the tissue concentrations of these steroids are several-fold higher than those in plasma, suggesting tumor accumulation of these estrogens. Expand
Aromatase and its inhibitors: significance for breast cancer therapy.
TLDR
The introduction of the so-called phase III inhibitors, which display high affinity and specificity towards aromatase, are proving to be more effective than tamoxifen and are being approved as first-line therapy for elderly women with advanced disease. Expand
Aromatase deficiency in male and female siblings caused by a novel mutation and the physiological role of estrogens.
TLDR
A novel mutation in the CYP19 gene in a sister and brother exhibited the cardinal features of the aromatase deficiency syndrome as recently defined and was reported on. Expand
Impairment of spermatogenesis in mice lacking a functional aromatase (cyp 19) gene.
TLDR
It is indicated that local expression of aromatase is essential for spermatogenesis and provide evidence for a direct action of estrogen on male germ cell development and thus fertility. Expand
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