Sources of Variability in a Synthetic Gene Oscillator

Abstract

Synthetic gene oscillators are small, engineered genetic circuits that produce periodic variations in target protein expression. Like other gene circuits, synthetic gene oscillators are noisy and exhibit fluctuations in amplitude and period. Understanding the origins of such variability is key to building predictive models that can guide the rational design… (More)
DOI: 10.1371/journal.pcbi.1004674

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