Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264

  title={Sources of Diversity in Bactobolin Biosynthesis by Burkholderia thailandensis E264},
  author={Gavin S. Carr and Mohammad R Seyedsayamdost and Josephine R. Chandler and E Peter Greenberg and Jon Clardy},
  booktitle={Organic letters},
A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family. 

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Bl € ocker , H . ; M € uller , R

S. C. Wenzel, B. Kunze, B. Silakowski, M. Scharfe

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