Sources of Ca2+ in relation to generation of acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery.

@article{Fukao1997SourcesOC,
  title={Sources of Ca2+ in relation to generation of acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery.},
  author={Mitsuhiro Fukao and Yuichi Hattori and Morio Kanno and Ichiro Sakuma and Akira Kitabatake},
  journal={British journal of pharmacology},
  year={1997},
  volume={120 7},
  pages={1328-34}
}
1. The aim of the present study was to identify the sources of Ca2+ contributing to acetylcholine (ACh)-induced release of endothelium-derived hyperpolarizing factor (EDHF) from endothelial cells of rat mesenteric artery and to assess the pathway involved. The changes in membrane potentials of smooth muscles by ACh measured with the microelectrode technique were evaluated as a marker for EDHF release. 2. ACh elicited membrane hyperpolarization of smooth muscle cells in an endothelium-dependent… CONTINUE READING

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