Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans

  title={Sources and Significance of Plasma Levels of Catechols and Their Metabolites in Humans},
  author={David S. Goldstein and Graeme Eisenhofer and Irwin J. Kopin},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  pages={800 - 811}
Human plasma contains several catechols, including the catecholamines norepinephrine, epinephrine, and dopamine, their precursor, l-3,4-dihydroxyphenylalanine (l-DOPA), and their deaminated metabolites, dihydroxyphenylglycol, the main neuronal metabolite of norepinephrine, and dihydroxyphenylacetic acid, a deaminated metabolite of dopamine. Products of metabolism of catechols include 3-methoxytyrosine (from l-DOPA), homovanillic acid and dopamine sulfate (from dopamine), normetanephrine… 

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