Sources, metabolism, and regulation of circulating sphingosine-1-phosphate.

  title={Sources, metabolism, and regulation of circulating sphingosine-1-phosphate.},
  author={Monika Książek and Marta Chacińska and Adrian Chabowski and M Baranowski},
  journal={Journal of lipid research},
  volume={56 7},
Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid that acts either as an intracellular messenger or as a ligand for its membrane receptors. S1P is a normal constituent of blood, where it is found both in plasma and blood cells. Compared with other cell types, sphingolipid metabolism in erythrocytes and platelets has unique features that allow the erythrocytes and platelets to accumulate S1P. In plasma, S1P is bound mainly to HDLs and albumin. Of note, metabolism and biological activity… CONTINUE READING


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