Source and fate of circulating citrulline.

@article{Windmueller1981SourceAF,
  title={Source and fate of circulating citrulline.},
  author={H. G. Windmueller and A. E. Spaeth},
  journal={The American journal of physiology},
  year={1981},
  volume={241 6},
  pages={E473-80}
}
Previous work has demonstrated a continuous release of citrulline from the small intestine into the circulation. To evaluate the physiologic significance of this process, we have now measured citrulline uptake and release by isolated, perfused livers and, through surgical means and arteriovenous difference measurements, by various organs of the rat in vivo. Intestinally derived citrulline, an end product of glutamine nitrogen metabolism, passes through the liver without appreciable uptake. No… CONTINUE READING
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