Sound conditioning protects hearing by activating the hypothalamic–pituitary–adrenal axis

@article{Tahera2007SoundCP,
  title={Sound conditioning protects hearing by activating the hypothalamic–pituitary–adrenal axis},
  author={Yeasmin Tahera and Inna Meltser and Peter Johansson and Hazim Salman and Barbara Canlon},
  journal={Neurobiology of Disease},
  year={2007},
  volume={25},
  pages={189-197}
}
Protecting the auditory system with glucocorticoids
The Mouse Cochlea Expresses a Local Hypothalamic-Pituitary-Adrenal Equivalent Signaling System and Requires Corticotropin-Releasing Factor Receptor 1 to Establish Normal Hair Cell Innervation and Cochlear Sensitivity
TLDR
An essential role for CRFR1 in auditory system development and function is described, and the first description of a complete HPA equivalent signaling system resident within the cochlea is offered.
The glucocorticoid antagonist mifepristone attenuates sound‐induced long‐term deficits in auditory nerve response and central auditory processing in female rats
TLDR
It is demonstrated that higher corticosterone levels during acoustic trauma in female rats is highly correlated with a decline of auditory fiber responses in high‐frequency cochlear regions, and that hearing thresholds and the outer hair cell functions are left unaffected.
The role of glucocorticoid receptors and mitogen-regulated protein kinases in the cochlea
TLDR
The results demonstrate that GR plays an unequivocal role in modulating auditory sensitivity and BDNF acts through receptor tyrosine kinase TrkB followed by the downstream activation of ERKs and p38 cascades, which is a critical factor for determining the overall sensitivity to acoustic trauma.
The Cochlear CRF Signaling Systems and their Mechanisms of Action in Modulating Cochlear Sensitivity and Protection Against Trauma
TLDR
A novel cochlear signaling system is discovered that is molecularly equivalent to the classic hypothalamic–pituitary–adrenal (HPA) axis and functions to balance auditory sensitivity and susceptibility to noise-induced hearing loss, and also protects against cellular metabolic insults resulting from exposures to ototoxic drugs.
Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise
TLDR
A wide range of topics are covered, including a cochlear-based CRF signaling system that mirrors the hypothalamic-pituitary-adrenal axis, central Master clocks and peripheral clocks resident in many tissues of the body, and the molecular biology of glucocorticoid receptors.
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Suppression of apoptosis occurs in the cochlea by sound conditioning
TLDR
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TLDR
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TLDR
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