Sound conditioning protects hearing by activating the hypothalamic–pituitary–adrenal axis

  title={Sound conditioning protects hearing by activating the hypothalamic–pituitary–adrenal axis},
  author={Yeasmin Tahera and Inna Meltser and Peter Johansson and Hazim Salman and Barbara Canlon},
  journal={Neurobiology of Disease},
Protecting the auditory system with glucocorticoids
The Mouse Cochlea Expresses a Local Hypothalamic-Pituitary-Adrenal Equivalent Signaling System and Requires Corticotropin-Releasing Factor Receptor 1 to Establish Normal Hair Cell Innervation and Cochlear Sensitivity
An essential role for CRFR1 in auditory system development and function is described, and the first description of a complete HPA equivalent signaling system resident within the cochlea is offered.
The glucocorticoid antagonist mifepristone attenuates sound‐induced long‐term deficits in auditory nerve response and central auditory processing in female rats
It is demonstrated that higher corticosterone levels during acoustic trauma in female rats is highly correlated with a decline of auditory fiber responses in high‐frequency cochlear regions, and that hearing thresholds and the outer hair cell functions are left unaffected.
The role of glucocorticoid receptors and mitogen-regulated protein kinases in the cochlea
The results demonstrate that GR plays an unequivocal role in modulating auditory sensitivity and BDNF acts through receptor tyrosine kinase TrkB followed by the downstream activation of ERKs and p38 cascades, which is a critical factor for determining the overall sensitivity to acoustic trauma.
The Cochlear CRF Signaling Systems and their Mechanisms of Action in Modulating Cochlear Sensitivity and Protection Against Trauma
A novel cochlear signaling system is discovered that is molecularly equivalent to the classic hypothalamic–pituitary–adrenal (HPA) axis and functions to balance auditory sensitivity and susceptibility to noise-induced hearing loss, and also protects against cellular metabolic insults resulting from exposures to ototoxic drugs.
Corticotropin Releasing Factor Signaling in the Mammalian Cochlea: An Integrative Niche for Cochlear Homeostatic Balance Against Noise
A wide range of topics are covered, including a cochlear-based CRF signaling system that mirrors the hypothalamic-pituitary-adrenal axis, central Master clocks and peripheral clocks resident in many tissues of the body, and the molecular biology of glucocorticoid receptors.


NF‐κB mediated glucocorticoid response in the inner ear after acoustic trauma
It is demonstrated how GR can directly modulate hearing sensitivity in response to a moderate acoustic trauma that results in a hearing loss (10–30 dB), and several factors define the responsiveness of the inner ear to GC, including the availability of ligand or receptor, and the nuclear translocation of GR and NF‐κB.
Suppression of apoptosis occurs in the cochlea by sound conditioning
It is shown that acoustic trauma causes the release of cytochrome c from the mitochondria into the cytoplasm, and a decrease in bcl‐2 immunoreactivity in the outer hair cells, and this suggests that bCl‐2 plays an important role in the regulation of hair cell death, and provides evidence that b cl‐2 acts as an inducible neuroprotective gene that is upregulated by sound conditioning.
Differential Impact of Audiogenic Stressors on Lewis and Fischer Rats: Behavioral, Neurochemical, and Endocrine Variations
Post-mortem analyses revealed that noise exposure induced strain-dependent variations of corticotropin-releasing hormone (CRH) across several brain regions, which was evident irrespective of whether the rats were noise exposed in a familiar (home cage) or unfamiliar environment.
Neuroendocrine and Behavioral Responses and Brain Pattern of c‐fos Induction Associated with Audiogenic Stress
  • S. Watson
  • Biology
    Journal of neuroendocrinology
  • 1997
The present study determined simultaneously the behavioural, neuroendocrine and regional brain activity, using semi‐quantitative analysis of c‐fos mRNA induction, produced by 30 min of auditory
Restraint stress and protection from acoustic injury in mice
Protective mechanisms of sound conditioning.
Different sound-conditioning paradigms have been proven successful in preventing pathological changes to the auditory system and the possible biological mechanisms underlying this phenomenon are discussed.
Sound conditioning reduces noise-induced permanent threshold shift in mice
Neurotrophins, NMDA receptors, and nitric oxide in development and protection of the auditory system.
Recent progress has been made regarding the prevention of aminoglycoside-induced hearing loss in the adult guinea pig and the mechanisms leading to hair cell damage are discussed in this paper.