Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

@inproceedings{Galea2011SostDB,
  title={Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4},
  author={Gabriel L Galea and Andrew Sunters and Lee B Meakin and Gul Zaman and Toshihiro Sugiyama and Lance Edward Lanyon and Joanna S. Price},
  booktitle={FEBS letters},
  year={2011}
}
Sclerostin is a potent inhibitor of bone formation which is down-regulated by mechanical loading. To investigate the mechanisms involved we subjected Saos2 human osteoblastic cells to short periods of dynamic strain and used quantitative reverse transcriptase polymerase chain reaction to compare their responses to unstrained controls. Strain-induced Sost down-regulation was recapitulated by cyclo-oxygenase-2-mediated PGE2, acting through the EP4 receptor, whereas strain-related up-regulation of… CONTINUE READING
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Discovery of a potent and selective agonist of the prostaglandin EP4 receptor

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