Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain

@inproceedings{Wiedemann2007SortingSO,
  title={Sorting switch of mitochondrial presequence translocase involves coupling of motor module to respiratory chain},
  author={Nils Wiedemann and Martin van der Laan and Dana P. Hutu and Peter Rehling and Nikolaus Pfanner},
  booktitle={The Journal of cell biology},
  year={2007}
}
The mitochondrial presequence translocase transports preproteins to either matrix or inner membrane. Two different translocase forms have been identified: the matrix transport form, which binds the heat-shock protein 70 (Hsp70) motor, and the inner membrane-sorting form, which lacks the motor but contains translocase of inner mitochondrial membrane 21 (Tim21). The sorting form interacts with the respiratory chain in a Tim21-dependent manner. It is unknown whether the respiratory chain-bound… CONTINUE READING

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