Sorting signals required for trafficking of the cysteine-rich acidic repetitive transmembrane protein in Trypanosoma brucei.

@article{Qiao2006SortingSR,
  title={Sorting signals required for trafficking of the cysteine-rich acidic repetitive transmembrane protein in Trypanosoma brucei.},
  author={Xugang Qiao and Bin-Fay Chuang and Yamei Jin and Madhavi Muranjan and C F Hung and Pei-Tseng Lee and Mary Gwo-Shu Lee},
  journal={Eukaryotic cell},
  year={2006},
  volume={5 8},
  pages={1229-42}
}
In trypanosomatids, endocytosis and exocytosis are restricted to the flagellar pocket (FP). The cysteine-rich acidic repetitive transmembrane (CRAM) protein is located at the FP of Trypanosoma brucei and potentially functions as a receptor or an essential component for lipoprotein uptake. We characterized sorting determinants involved in efficient trafficking of CRAM to and from the FP of T. brucei. Previous studies indicated the presence of signals in the CRAM C terminus, specific for its… CONTINUE READING