Sorting out of normal and virus-transformed cells in cellular aggregates

@article{Gershman1976SortingOO,
  title={Sorting out of normal and virus-transformed cells in cellular aggregates},
  author={Howard Gershman and John W Drumm and L Culp},
  journal={The Journal of Cell Biology},
  year={1976},
  volume={68},
  pages={276 - 286}
}
The sorting-out behavior (self-segregation of two cell types from mixtures of the two) of five different established cell lines was studied. Eight of the ten possible binary combinations of these lines, cultured as cellular aggregates, were examined. Mouse BALB/c 3T3 cells sorted out internally to the corresponding malignant SV40 virus-transformed 3T3 cells. The transformed 3T3 line (SVT-2) did not sort out from a revertant line selected from SVT-2 cells by resistance to concanavalin A (con A… CONTINUE READING

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