Sorting out Toll Signals

@article{Fitzgerald2006SortingOT,
  title={Sorting out Toll Signals},
  author={Katherine A. Fitzgerald and Zhijian J Chen},
  journal={Cell},
  year={2006},
  volume={125},
  pages={834-836}
}
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism. 
25 Citations
6 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

References

Publications referenced by this paper.
Showing 1-6 of 6 references

divided the human genome into genic and nongenic regions and looked for patterns of at least 16 bases in length that occurred at least 40 times

  • Rigoutsos
  • 2006
1 Excerpt

TEIRESIAS’s unique advantage is its two-stage process of building longer patterns from shorter ones

  • Xie
  • 2005
1 Excerpt

Nat

  • M. Yamamoto, S. Sato, +6 authors S. Akira
  • Immunol. 4, 1144–1150.
  • 2003

Annu

  • S. McLaughlin, J. Wang, A. Gambhir, D. Murray
  • Rev. Biophys. Biomol. Struct. 31, 151–175.
  • 2002
1 Excerpt

J

  • P. Y. Perera, T. N. Mayadas, +4 authors S. N. Vogel
  • Immunol. 166, 574–581.
  • 2001

Infect

  • T. H. Flo, L. Ryan, +5 authors T. Espevik
  • Immun. 68, 6770–6776.
  • 2000
1 Excerpt

Similar Papers

Loading similar papers…