Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells.

@article{Leung2000SortingOM,
  title={Sorting of membrane and fluid at the apical pole of polarized Madin-Darby canine kidney cells.},
  author={Sangkug Leung and W Giovanni Ruiz and Gerard A. Apodaca},
  journal={Molecular biology of the cell},
  year={2000},
  volume={11 6},
  pages={
          2131-50
        }
}
When fluid-phase markers are internalized from opposite poles of polarized Madin-Darby canine kidney cells, they accumulate in distinct apical and basolateral early endosomes before meeting in late endosomes. Recent evidence suggests that significant mixing of apically and basolaterally internalized membrane proteins occurs in specialized apical endosomal compartments, including the common recycling endosome and the apical recycling endosome (ARE). The relationship between these latter… CONTINUE READING