Sorting of lysosomal proteins.

  title={Sorting of lysosomal proteins.},
  author={Thomas Braulke and Juan S Bonifacino},
  journal={Biochimica et biophysica acta},
  volume={1793 4},
Lysosomes are composed of soluble and transmembrane proteins that are targeted to lysosomes in a signal-dependent manner. The majority of soluble acid hydrolases are modified with mannose 6-phosphate (M6P) residues, allowing their recognition by M6P receptors in the Golgi complex and ensuing transport to the endosomal/lysosomal system. Other soluble enzymes and non-enzymatic proteins are transported to lysosomes in an M6P-independent manner mediated by alternative receptors such as the… CONTINUE READING
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