Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone.

@article{Faras2015SortingOD,
  title={Sorting of Dendritic and Axonal Vesicles at the Pre-axonal Exclusion Zone.},
  author={Ginny G. Far{\'i}as and Carlos Minchola Guardia and Dylan J. Britt and Xiaoli Guo and Juan S Bonifacino},
  journal={Cell reports},
  year={2015},
  volume={13 6},
  pages={
          1221-1232
        }
}
Polarized sorting of newly synthesized proteins to the somatodendritic and axonal domains of neurons occurs by selective incorporation into distinct populations of vesicular transport carriers. An unresolved issue is how the vesicles themselves are sorted to their corresponding neuronal domains. Previous studies concluded that the axon initial segment (AIS) is an actin-based filter that selectively prevents passage of somatodendritic vesicles into the axon. We find, however, that most… CONTINUE READING
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