Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.

@article{Williams2004SortingN1,
  title={Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.},
  author={Ross Williams and Thomas Schl{\"u}ter and Marnie S Roberts and Peter Knauth and Ralf Bohnensack and Daniel F Cutler},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 7},
  pages={
          3095-105
        }
}
The transient appearance of P-selectin on the surface of endothelial cells helps recruit leukocytes into sites of inflammation. The tight control of cell surface P-selectin on these cells depends on regulated exocytosis of Weibel-Palade bodies where the protein is stored and on its rapid endocytosis. After endocytosis, P-selectin is either sorted via endosomes and the Golgi apparatus for storage in Weibel-Palade bodies or targeted to lysosomes for degradation. A potential player in this complex… CONTINUE READING

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