Sorting nexin 1 down-regulation promotes colon tumorigenesis.

  title={Sorting nexin 1 down-regulation promotes colon tumorigenesis.},
  author={Lananh N. Nguyen and Matthew S. Holdren and Anthony P. Nguyen and Momoko H Furuya and Michele Bianchini and Estrella Mariel Levy and Jos{\'e} Mordoh and Annie Liu and Gabriela D Guncay and Jean S. Campbell and W Tony Parks},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={12 23},
PURPOSE Colon cancer is one of the most common human malignancies, yet studies have only begun to identify the multiple mechanisms that underlie the development of this tumor. In this study, we have identified a novel mechanism, dysregulation of endocytic sorting, which promotes colon cancer development. EXPERIMENTAL DESIGN Immunohistochemical and microarray analyses were done on human colon cancer tissue specimens to determine the levels of one endocytic protein, sorting nexin 1 (SNX1… CONTINUE READING


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