Sortilins in neurotrophic factor signaling.

@article{Glerup2014SortilinsIN,
  title={Sortilins in neurotrophic factor signaling.},
  author={Simon Glerup and Anders Nykjaer and Christian Bjerggaard Vaegter},
  journal={Handbook of experimental pharmacology},
  year={2014},
  volume={220},
  pages={165-89}
}
The sortilin family of Vps10p-domain receptors includes sortilin, SorLA, and SorCS1-3. These type-I transmembrane receptors predominate in distinct neuronal tissues, but expression is also present in certain specialized non-neuronal cell populations including hepatocytes and cells of the immune system. The biology of sortilins is complex as they participate in both cell signaling and in intracellular protein sorting. Sortilins function physiologically in signaling by pro- and mature… CONTINUE READING

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