Sortilin regulates progranulin action in castration-resistant prostate cancer cells.

Abstract

The growth factor progranulin is as an important regulator of transformation in several cellular systems. We have previously demonstrated that progranulin acts as an autocrine growth factor and stimulates motility, proliferation, and anchorage-independent growth of castration-resistant prostate cancer cells, supporting the hypothesis that progranulin may… (More)
DOI: 10.1210/en.2014-1590

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