Sortilin is essential for proNGF-induced neuronal cell death

  title={Sortilin is essential for proNGF-induced neuronal cell death},
  author={A. Nykjaer and Ramee Lee and K. Teng and P. Jansen and P. Madsen and M. Nielsen and C. Jacobsen and Marco Kliemannel and E. Schwarz and T. Willnow and B. Hempstead and C. M. Petersen},
  • A. Nykjaer, Ramee Lee, +9 authors C. M. Petersen
  • Published 2004
  • Biology, Medicine
  • Nature
  • Sortilin (∼95 kDa) is a member of the recently discovered family of Vps10p-domain receptors, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It acts as a receptor for neurotensin, but predominates in regions of the nervous system that neither synthesize nor respond to this neuropeptide, suggesting that sortilin has additional roles. Sortilin is expressed during embryogenesis in areas where nerve growth factor (NGF) and its precursor, proNGF, have well… CONTINUE READING
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