Sortilin is essential for proNGF-induced neuronal cell death

@article{Nykjaer2004SortilinIE,
  title={Sortilin is essential for proNGF-induced neuronal cell death},
  author={Anders Nykjaer and Ramee Lee and Kenneth K. Teng and Pernille Jansen and Peder Madsen and Morten Schallburg Nielsen and Christian Jacobsen and Marco Kliemannel and Elisabeth Schwarz and Thomas E. Willnow and Barbara L. Hempstead and Claus Munck Petersen},
  journal={Nature},
  year={2004},
  volume={427},
  pages={843-848}
}
Sortilin (∼95 kDa) is a member of the recently discovered family of Vps10p-domain receptors, and is expressed in a variety of tissues, notably brain, spinal cord and muscle. It acts as a receptor for neurotensin, but predominates in regions of the nervous system that neither synthesize nor respond to this neuropeptide, suggesting that sortilin has additional roles. Sortilin is expressed during embryogenesis in areas where nerve growth factor (NGF) and its precursor, proNGF, have well… 
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TLDR
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Proneurotrophin-3 Is a Neuronal Apoptotic Ligand: Evidence for Retrograde-Directed Cell Killing
TLDR
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Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation*
TLDR
Endocytosis and cleavage of proneurotrophins produce processed forms of neurotrophins that are capable of inducing Trk activation, and it is found that proBDNF induces activation of TrkB in cerebellar granule neurons and thatProBDNF cleavage by furin and metalloproteases facilitates this effect.
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