Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

@article{Chen2005SortilinCI,
  title={Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.},
  author={Zhe-yu Chen and Alessandro Ieraci and Henry Teng and Henning Dall and Chui-Xiang Meng and Daniel G. Herrera and Anders Nykjaer and Barbara L. Hempstead and Francis B. S. Lee},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2005},
  volume={25 26},
  pages={6156-66}
}
Brain-derived neurotrophic factor (BDNF), after activity-dependent secretion from neurons, modulates critical nervous system functions. Recently, a variant in the human bdnf gene, resulting in a valine to methionine substitution in the prodomain, has been shown to lead to defective regulated secretion from neurons and memory impairment. Here, we report a novel function for a Vps10p domain protein, sortilin, in controlling BDNF sorting to the regulated secretory pathway. Sortilin interacts… CONTINUE READING
Highly Influential
This paper has highly influenced a number of papers. REVIEW HIGHLY INFLUENTIAL CITATIONS