Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.

@article{Kwon2011SortilinAW,
  title={Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.},
  author={Sunjong Kwon and Jan L Christian},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 24},
  pages={
          21876-85
        }
}
Transforming growth factor (TGF)-β family proteins are synthesized as precursors that are cleaved to generate an active ligand. Previous studies suggest that TGF-β activity can be controlled by lysosomal degradation of both precursor proteins and ligands, but how these soluble proteins are trafficked to the lysosome is incompletely understood. The current studies show that sortilin selectively co-immunoprecipitates with the cleaved prodomain and/or precursor form of TGF-β family members… CONTINUE READING

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