Sortilin and SorLA Regulate Neuronal Sorting of Trophic and Dementia-Linked Proteins

  title={Sortilin and SorLA Regulate Neuronal Sorting of Trophic and Dementia-Linked Proteins},
  author={Lone Tjener Pallesen and Christian Bjerggaard Vaegter},
  journal={Molecular Neurobiology},
Sortilin and SorLA are members of the Vps10p domain receptor family, the Sortilins, which comprise five type I transmembrane receptors differentially expressed in neuronal tissues of the central and peripheral nervous system. Since the identification of sortilin in 1997, members of this receptor family are recognized as sorting receptors primarily in the trans-Golgi network, interacting with a wide range of ligands comprising other transmembrane receptors as well as soluble proteins from… CONTINUE READING


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