Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.

  title={Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase.},
  author={Morten S Nielsen and Christian Jacobsen and Gunilla Olivecrona and Jorgen Gliemann and Claus Munck Petersen},
  journal={The Journal of biological chemistry},
  volume={274 13},
Lipoprotein lipase and the receptor-associated protein (RAP) bind to overlapping sites on the low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor (LRP). We have investigated if lipoprotein lipase interacts with the RAP binding but structurally distinct receptor sortilin/neurotensin receptor-3. We show, by chemical cross-linking and surface plasmon resonance analysis, that soluble sortilin binds lipoprotein lipase with an affinity similar to that of LRP. The binding… CONTINUE READING


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