Sorcin regulates excitation-contraction coupling in the heart.

  title={Sorcin regulates excitation-contraction coupling in the heart.},
  author={Marian B. Meyers and Avi G Fischer and Yan-jie Sun and Coeli M. Lopes and Tibor Rohacs and Tomoe Y. Nakamura and Ying-ying Zhou and Paul C.H. Lee and Ruth A. Altschuld and Sylvia A. McCune and William A Coetzee and Glenn I. Fishman},
  journal={The Journal of biological chemistry},
  volume={278 31},
Sorcin is a penta-EF hand Ca2+-binding protein that associates with both cardiac ryanodine receptors and L-type Ca2+ channels and has been implicated in the regulation of intracellular Ca2+ cycling. To better define the function of sorcin, we characterized transgenic mice in which sorcin was overexpressed in the heart. Transgenic mice developed normally with no evidence of cardiac hypertrophy and no change in expression of other calcium regulatory proteins. In vivo hemodynamics revealed… CONTINUE READING
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