Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation

@inproceedings{Hallock2016Sorbs1A,
  title={Sorbs1 and -2 Interact with CrkL and Are Required for Acetylcholine Receptor Cluster Formation},
  author={Peter T. Hallock and Sherry T Chin and Steven P Blais and Thomas A Neubert and David J Glass},
  booktitle={Molecular and cellular biology},
  year={2016}
}
Crk and CrkL are noncatalytic adaptor proteins necessary for the formation of neuromuscular synapses which function downstream of muscle-specific kinase (MuSK), a receptor tyrosine kinase expressed in skeletal muscle, and the MuSK binding protein Dok-7. How Crk/CrkL regulate neuromuscular endplate formation is not known. To better understand the roles of… CONTINUE READING