Sorbitol permease: an apical membrane transporter in cultured renal papillary epithelial cells.

@article{Garty1991SorbitolPA,
  title={Sorbitol permease: an apical membrane transporter in cultured renal papillary epithelial cells.},
  author={Haim Garty and Timothy J. Furlong and D. E. Ellis and Kenneth R. Spring},
  journal={The American journal of physiology},
  year={1991},
  volume={260 5 Pt 2},
  pages={F650-6}
}
The efflux of sorbitol from the rabbit papillary epithelial cell line PAP-HT25 occurs through a specific transport pathway, which we denote the "sorbitol permease." The permease was studied by measuring cell volume changes that accompanied osmotic swelling and by determination of the sorbitol efflux from plasma membrane vesicles. The cell volume studies showed that sorbitol efflux in response to hypotonicity occurred only across the apical membrane of the cells and that loss of sorbitol was the… CONTINUE READING
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