Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.

@article{Uzozie2014SorbitolDO,
  title={Sorbitol dehydrogenase overexpression and other aspects of dysregulated protein expression in human precancerous colorectal neoplasms: a quantitative proteomics study.},
  author={Anuli Christiana Uzozie and Paolo Nanni and Teresa Staiano and Jonas Grossmann and Simon Barkow-Oesterreicher and Jerry W Shay and Amit K Tiwari and Federico Buffoli and Endre Laczk{\'o} and Giancarlo Marra},
  journal={Molecular & cellular proteomics : MCP},
  year={2014},
  volume={13 5},
  pages={1198-218}
}
Colorectal adenomas are cancer precursor lesions of the large bowel. A multitude of genomic and epigenomic changes have been documented in these preinvasive lesions, but their impact on the protein effectors of biological function has not been comprehensively explored. Using shotgun quantitative MS, we exhaustively investigated the proteome of 30 colorectal adenomas and paired samples of normal mucosa. Total protein extracts were prepared from these tissues (prospectively collected during… CONTINUE READING
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