Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus.

@article{Bringmann2003SorbicillactoneAA,
  title={Sorbicillactone A: a structurally unprecedented bioactive novel-type alkaloid from a sponge-derived fungus.},
  author={Gerhard Bringmann and Gerhard Lang and J{\"o}rg M{\"u}hlbacher and Karsten Schaumann and Silke Steffens and Petr G Rytik and Ute Hentschel and Joachim Morschh{\"a}user and Werner E G M{\"u}ller},
  journal={Progress in molecular and subcellular biology},
  year={2003},
  volume={37},
  pages={
          231-53
        }
}
This chapter deals with the discovery of sorbicillactone A, as an illustrative example of the fruitful cooperation within BIOTECmarin--its isolation and chemical characterization, and its biological activities. Sorbicillactone A was isolated from a strain of Penicillium chrysogenum cultured from a sample of the Mediterranean sponge Ircinia fasciculata; it possesses a unique bicyclic lactone structure, seemingly derived from sorbicillin. Among the numerous known sorbicillin-derived structures… CONTINUE READING
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