Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells.

@article{Sprinzl2013SorafenibPC,
  title={Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells.},
  author={Martin Franz Sprinzl and Florian Reisinger and Andreas Puschnik and Marc Ringelhan and Kerstin Ackermann and Daniel Hartmann and Matthias Schiemann and Arndt Weinmann and Peter R. Galle and Marcus Schuchmann and Helmut Friess and G. F. Otto and Mathias Heikenwalder and Ulrike Protzer},
  journal={Hepatology},
  year={2013},
  volume={57 6},
  pages={2358-68}
}
UNLABELLED Alternatively polarized macrophages (Mϕ) shape the microenvironment of hepatocellular carcinoma (HCC) and temper anticancer immune responses. We investigated if sorafenib alters the HCC microenvironment by restoring classical macrophage polarization and triggering tumor-directed natural killer (NK) cell responses. In vivo experiments were conducted with sorafenib (25 mg/kg)-treated C57BL/6 wildtype as well as hepatitis B virus (HBV) and lymphotoxin transgenic mice with and without… CONTINUE READING
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