Sorafenib inhibits liver cancer growth by decreasing mTOR, AKT, and PI3K expression.

  title={Sorafenib inhibits liver cancer growth by decreasing mTOR, AKT, and PI3K expression.},
  author={Chi-zhi Zhang and Xiaodong Wang and Hong-Wei Wang and Yue Cai and Li-qin Chao},
  journal={Journal of B.U.ON. : official journal of the Balkan Union of Oncology},
  volume={20 1},
PURPOSE The purpose of this study was to determine the impact of sorafenib on PI3K/AKT/mTOR signaling pathway and to further define its mechanism for treating hepatocellular carcinoma (HCC). METHODS Human SMMC-7721 hepatic carcinoma cells were treated with or without 4 μmoL/L sorafenib. SMMC- 7721 cells were harvested at various time points (0-48 hrs) and assessed for changes in PI3K, mTOR, and AKT protein and mRNA levels. RESULTS Human SMMC-7721 hepatic tumor cells exposed to sorafenib had… CONTINUE READING
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