Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3.

Abstract

Glioblastoma is the most common type of primary brain tumor and is rapidly progressive with few treatment options. Here, we report that sorafenib (< or =10 micromol/L) inhibited cell proliferation and induced apoptosis in two established cell lines (U87 and U251) and two primary cultures (PBT015 and PBT022) from human glioblastomas. The effects of sorafenib… (More)
DOI: 10.1158/1535-7163.MCT-09-0947

Topics

6 Figures and Tables

Cite this paper

@article{Yang2010SorafenibIG, title={Sorafenib induces growth arrest and apoptosis of human glioblastoma cells through the dephosphorylation of signal transducers and activators of transcription 3.}, author={Fan Yang and Christine Brown and Ralf Buettner and Michael Hedvat and Renate L Starr and Anna Scuto and Anne Schroeder and Michael C. Jensen and Richard L Jove}, journal={Molecular cancer therapeutics}, year={2010}, volume={9 4}, pages={953-62} }