Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1).

Abstract

We have previously shown that sorafenib, a multikinase inhibitor, exhibits cytotoxic effects on chronic lymphocytic leukemia (CLL) cells. Because the cellular microenvironment can protect CLL cells from drug-induced apoptosis, it is important to evaluate the effect of novel drugs in this context. Here we characterized the in vitro cytotoxic effects of… (More)
DOI: 10.2119/molmed.2011.00164

Topics

Cite this paper

@article{Fecteau2012SorafenibinducedAO, title={Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1).}, author={J F Fecteau and Ila Sri Bharati and Morgan O'Hayre and Tracy M. Handel and Thomas J. Kipps and Davorka Messmer}, journal={Molecular medicine}, year={2012}, volume={18}, pages={19-28} }