Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf.

@article{Chen2011SorafenibDI,
  title={Sorafenib derivatives induce apoptosis through inhibition of STAT3 independent of Raf.},
  author={Kuen-Feng Chen and Wei-Tien Tai and Jui-Wen Huang and Cheng-Yi Hsu and Wei-Lin Chen and Ann-lii Cheng and Pei-Jer Chen and C S Shiau},
  journal={European journal of medicinal chemistry},
  year={2011},
  volume={46 7},
  pages={2845-51}
}
STAT3 is a transcription factor that modulates survival-directed transcription. It is persistently activated in many human cancers. Literature has shown that sorafenib, Raf kinase inhibitor, reduces Phospho-STAT3 and induces cell death. A series of sorafenib derivatives were synthesized as new inhibitors for STAT3. Urea, sulfonamide, and carboxamide linkers brought out different SARs from the end of sorafenib. Urea and carboxamide linked derivatives showed greater inhibition against STAT3… CONTINUE READING

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