Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro.

  title={Sorafenib and Mek inhibition is synergistic in medullary thyroid carcinoma in vitro.},
  author={Yoon Woo Koh and Manisha H Shah and Kitty Agarwal and Samantha K. McCarty and Bon Seok Koo and Victoria J Brendel and Chaojie Wang and Kyle Porter and David Jarjoura and Motoyasu Saji and Matthew D. Ringel},
  journal={Endocrine-related cancer},
  volume={19 1},
  • Y. KohM. Shah M. Ringel
  • Published 1 February 2012
  • Biology, Medicine, Chemistry
  • Endocrine-related cancer
Clinical trials using kinase inhibitors have demonstrated transient partial responses and disease control in patients with progressive medullary thyroid cancer (MTC). The goal of this study was to identify potential combinatorial strategies to improve on these results using sorafenib, a multikinase inhibitor with activity in MTC, as a base compound to explore signaling that might predict synergystic interactions. Two human MTC cell lines, TT and MZ-CRC-1, which harbor endogenous C634W or M918T… 

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