Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.

  title={Sorafenib and HDAC inhibitors synergize to kill CNS tumor cells.},
  author={Yong Tang and Adly Yacoub and Hossein A. Hamed and Andrew Poklepovic and Gary W Tye and Steven Grant and Paul Dent},
  journal={Cancer biology & therapy},
  volume={13 7},
The present studies were designed to determine whether the multi-kinase inhibitor sorafenib (Nexavar) interacted with histone deacetylase inhibitors to kill glioblastoma and medulloblastoma cells. In a dose-dependent fashion sorafenib lethality was enhanced in multiple genetically disparate primary human glioblastoma isolates by the HDAC inhibitor sodium valproate (Depakote). Drug exposure reduced phosphorylation of p70 S6K and of mTOR. Similar data to that with valproate were also obtained… CONTINUE READING


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