SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.

@article{Glerup2013SorLACN,
  title={SorLA controls neurotrophic activity by sorting of GDNF and its receptors GFRα1 and RET.},
  author={Simon Glerup and Maria Lume and Ditte Olsen and Jens Randel Nyengaard and Christian Bjerggaard Vaegter and Camilla Gustafsen and Erik Ilso Christensen and Mads Kjolby and Anders Hay-Schmidt and Dirk Bender and Peder Madsen and Mart Saarma and Anders Nykjaer and Claus Munck Petersen},
  journal={Cell reports},
  year={2013},
  volume={3 1},
  pages={186-99}
}
Glial cell-line-derived neurotrophic factor (GDNF) is a potent neurotrophic factor that has reached clinical trials for Parkinson's disease. GDNF binds to its coreceptor GFRα1 and signals through the transmembrane receptor tyrosine kinase RET, or RET independently through NCAM or syndecan-3. Whereas the GDNF signaling cascades are well described, cellular turnover and trafficking of GDNF and its receptors remain poorly characterized. Here, we find that SorLA acts as sorting receptor for the… CONTINUE READING

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