Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery.

@article{Feichtinger2014SonoporationIT,
  title={Sonoporation increases therapeutic efficacy of inducible and constitutive BMP2/7 in vivo gene delivery.},
  author={Georg Alexander Feichtinger and Anna Theresa Hofmann and Paul Slezak and Sebastian Sch{\"u}tzenberger and Martin Kaipel and Ernst Schwartz and Anne Neef and Nikolitsa Nomikou and Thomas Nau and Martijn van Griensven and A. P. McHale and Heinz Redl},
  journal={Human gene therapy methods},
  year={2014},
  volume={25 1},
  pages={
          57-71
        }
}
An ideal novel treatment for bone defects should provide regeneration without autologous or allogenous grafting, exogenous cells, growth factors, or biomaterials while ensuring spatial and temporal control as well as safety. Therefore, a novel osteoinductive nonviral in vivo gene therapy approach using sonoporation was investigated in ectopic and orthotopic models. Constitutive or regulated, doxycycline-inducible, bone morphogenetic protein 2 and 7 coexpression plasmids were repeatedly applied… CONTINUE READING
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