Sonoporation by ultrasound-activated microbubble contrast agents: effect of acoustic exposure parameters on cell membrane permeability and cell viability.

@article{Karshafian2009SonoporationBU,
  title={Sonoporation by ultrasound-activated microbubble contrast agents: effect of acoustic exposure parameters on cell membrane permeability and cell viability.},
  author={Raffi Karshafian and Peter D Bevan and Ross Williams and Sanya Samac and Peter N. Burns},
  journal={Ultrasound in medicine & biology},
  year={2009},
  volume={35 5},
  pages={847-60}
}
This work investigates the effect of ultrasound exposure parameters on the sonoporation of KHT-C cells in suspension by perflutren microbubbles. Variations in insonating acoustic pressure (0.05 to 3.5 MPa), pulse frequency (0.5 to 5.0 MHz), pulse repetition frequency (10 to 3000 Hz), pulse duration (4 to 32 micros) and insonation time (0.1 to 900 s) were studied. The number of cells permeabilised to a fluorescent tracer molecule (70 kDa FITC-dextran) and the number of viable cells were measured… CONTINUE READING

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