Sonographic detection of central nervous system defects in the first trimester of pregnancy

@article{Engels2016SonographicDO,
  title={Sonographic detection of central nervous system defects in the first trimester of pregnancy},
  author={Alexander C. Engels and Luc Joyeux and Casey Brantner and Bart De Keersmaecker and Luc de Catte and David Baud and Jan A Deprest and Tim van Mieghem},
  journal={Prenatal Diagnosis},
  year={2016},
  volume={36},
  pages={266 - 273}
}
The fetal central nervous system can already be examined in the first trimester of pregnancy. Acrania, alobar holoprosencephaly, cephaloceles, and spina bifida can confidently be diagnosed at that stage and should actively be looked for in every fetus undergoing first‐trimester ultrasound. For some other conditions, such as vermian anomalies and agenesis of the corpus callosum, markers have been identified, but the diagnosis can only be confirmed in the second trimester of gestation. For these… 
View on Wiley
gyneco-online.com
32 Citations
Highly Influential Citations
2
Background Citations
9
Methods Citations
1

32 Citations

Citation Type

Citation Type

Central Nervous System Anomalies Detectable in the First Trimester
TLDR
First trimester ultrasound could be useful for early detection of some CNS anomalies, but caution could be used for others, particularly in counseling couples about prognostic significant of ultrasound findings.
Sonographic detection of open spina bifida in the first trimester: review of the literature
TLDR
The objective of this review is to summarize the different techniques described regarding prenatal diagnosis of open spina bifida in the first trimester of pregnancy.
Prenatally diagnosed developmental abnormalities of the central nervous system and genetic syndromes: A practical review
TLDR
General principles of the genetic work‐up for fetuses with CNS defects are reviewed and categories of genetic causes of prenatally diagnosed CNS phenotypes are reviewed.
Prenatally diagnosed developmental abnormalities of the central nervous system and genetic syndromes: A practical review.
TLDR
General principles of the genetic work-up for fetuses with CNS defects are reviewed and categories of genetic causes of prenatally diagnosed CNS phenotypes are reviewed.
Principles of first trimester screening in the age of non-invasive prenatal diagnosis: screening for other major defects and pregnancy complications
TLDR
Detailed ultrasound examination results in the detection of about half of major structural defects, determination of a very accurate gestational age, and identification of multiple pregnancies as well as their chorionicity.
Autopsy Findings of Central Nervous System Anomalies in Intact Fetuses Following Termination of Pregnancy After Prenatal Ultrasound Diagnosis
  • C. Struksnæs, H. Blaas, C. Vogt
  • Medicine
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2019
TLDR
In this study of autopsy findings of CNS anomalies in intact fetuses terminated after prenatal US diagnosis, neural tube defects were most common and it is necessary to continue the validation practice.
First trimester detection of fetal open spina bifida using BS/BSOB ratio
TLDR
First trimester BS/BSOB ratio has a high diagnostic accuracy in detecting fetuses with open spina bifida at first trimester ultrasound.
Clinical outcomes and neurodevelopmental outcome of prenatally diagnosed agenesis of corpus callosum in single center of Korea
TLDR
The results of this single-center study included positive neurodevelopmental outcomes for those with isolated ACC, however, despite the endeavor to counsel patients with prenatally diagnosed ACC, the delivery rate in the center was quite low.
Sonographic Development of the Pericallosal Vascularization in the First and Early Second Trimester of Pregnancy
TLDR
The pericallosal artery and its branches can be identified and measured from 11 weeks on, and the pericAllosal artery takes its characteristic course, which could be an early sonographic marker of abnormal development of the corpus callosum.
Ultrasound and Magnetic Resonance Imaging of Agenesis of the Corpus Callosum in Fetuses
TLDR
It is hypothesized that fetal frontal horn (FH) morphology and their proximity to the cavum septi pellucidi (CSP) can assist in suspecting complete agenesis of the corpus callosum (cACC) earlier than known indirect ultrasound (US) findings.
...
1
2
3
4
...

References

SHOWING 1-10 OF 101 REFERENCES
Sonoembryology and early prenatal diagnosis of neural anomalies
TLDR
The early development of the central nervous system (CNS), as described by embryologists and anatomists in modern embryological textbooks, is compared with sonoanatomic descriptions from two‐dimensional and three‐dimensional ultrasound studies, week by week in the first trimester.
The early diagnosis of neural tube defects
TLDR
It is concluded that transvaginal sonographic examination of the fetal skull before the 17th week of gestation is an accurate method for the detection of low NTDs.
First and early second trimester diagnosis of anomalies of the central nervous system.
TLDR
Routine use of safe and noninvasive transvaginal ultrasonography early in pregnancy for patients at risk of central nervous system formation and pathologic cerebral development can be diagnosed already in the first trimester of pregnancy.
First‐Trimester Sonographic Diagnosis of Holoprosencephaly
  • W. Sepulveda, V. Dezerega, C. Be
  • Medicine
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine
  • 2004
TLDR
Systematic identification of the butterfly sign at the time of sonographic assessment of nuchal translucency provides a valuable tool for the early screening of holoprosencephaly in the first trimester.
Abdominal ultrasound examination of the first-trimester fetus.
First trimester sonographic diagnosis of holoprosencephaly
First trimester diagnosis of holoprosencephaly with a Dandy‐Walker malformation by transvaginal ultrasonography.
TLDR
A singleton pregnancy is described in which holoprosencephaly associated with the Dandy-Walker malformation and a limb defect was diagnosed by transvaginal ultrasonography in the first trimester.
Prenatal screening and diagnosis of neural tube defects
TLDR
There are high rates of pregnancy termination for spina bifida in many European countries, but the use of new imagining techniques allow better prediction of outcome, and consequently a refinement of prenatal counselling.
Detecting open spina bifida at the 11–13‐week scan by assessing intracranial translucency and the posterior brain region: mid‐sagittal or axial plane?
  • R. Chaoui, K. Nicolaides
  • Medicine
    Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology
  • 2011
TLDR
Assessment of the posterior brain area should be undertaken in the mid-sagittal or axial plane for diagnosis of open spina bifida using axial planes of the fetal head, as suggested by some studies.
Fetal intracranial anatomy in the first trimester of pregnancy: transvaginal ultrasonographic evaluation
TLDR
Data including measurements of crown rump length, bi-parietal diameter, head circumference, hemispheric width, lateral ventricle width, LVW/HW ratio, thalamus and cerebellum may be useful in determining deviations from the normal and in expanding the range of prenatal diagnoses of fetal structural abnormalities in early pregnancy.
...
1
2
3
4
5
...