Sonofragmentation of molecular crystals.

@article{Zeiger2011SonofragmentationOM,
  title={Sonofragmentation of molecular crystals.},
  author={Brad W. Zeiger and Kenneth S. Suslick},
  journal={Journal of the American Chemical Society},
  year={2011},
  volume={133 37},
  pages={
          14530-3
        }
}
Possible mechanisms for the breakage of molecular crystals under high-intensity ultrasound were investigated using acetylsalicylic acid (aspirin) crystals as a model compound for active pharmaceutical ingredients. Surprisingly, kinetics experiments ruled out particle-particle collisions as a viable mechanism for sonofragmentation. Two other possible mechanisms (particle-horn and particle-wall collisions) were dismissed on the basis of decoupling experiments. Direct particle-shock wave… 

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References

SHOWING 1-10 OF 66 REFERENCES

Interparticle collisions driven by ultrasound.

The effects of high-intensity ultrasound on solid-liquid slurries were examined and Turbulent flow and shock waves produced by acoustic cavitation were found to drive metal particles together at sufficiently high velocities to induce melting upon collision.

Effect of sonocrystallization on the habit and structure of gemfibrozil crystals

Specially engineered drug particles can solve solubility and formulation problems, which are major challenges for the pharmaceutical industry. Ultrasound irradiation induces acoustic streaming, and

High velocity interparticle collisions driven by ultrasound.

A simple kinematic model of the ultrasound-driven interparticle fusion predicts a melting criterion that is nonmonotonically dependent on particle size and is shown to be in agreement with experiment.

Ultrasonic irradiation of copper powder

Ultrasonic irradiation enhances the reactivity of metal surfaces. Because of this, the sonochemical activation of various metals has become a routine synthetic technique. The mechanisms of

Pressure during Sonoluminescence

Multibubble sonoluminescence (MBSL) spectra were collected from solutions containing volatile metal-containing compounds in silicone oil saturated with helium or argon. Ultrasonic irradiation of

Influence of Ultrasound on the Nucleation of Polymorphs of p-Aminobenzoic Acid

p-Aminobenzoic acid crystallizes in two different polymorphic forms:  the α-form and the β-form. The α-form crystals are needle-shaped, while the β-form crystals have a more favorable prismatic
...