Sonofragmentation of molecular crystals.

  title={Sonofragmentation of molecular crystals.},
  author={Brad W. Zeiger and Kenneth S. Suslick},
  journal={Journal of the American Chemical Society},
  volume={133 37},
Possible mechanisms for the breakage of molecular crystals under high-intensity ultrasound were investigated using acetylsalicylic acid (aspirin) crystals as a model compound for active pharmaceutical ingredients. Surprisingly, kinetics experiments ruled out particle-particle collisions as a viable mechanism for sonofragmentation. Two other possible mechanisms (particle-horn and particle-wall collisions) were dismissed on the basis of decoupling experiments. Direct particle-shock wave… 

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