• DOI:10.1021/OP050109X
• Corpus ID: 26976417

Sonocrystallization: The Use of Ultrasound for Improved Industrial Crystallization

@article{Ruecroft2005SonocrystallizationTU,
  title={Sonocrystallization: The Use of Ultrasound for Improved Industrial Crystallization},
  author={Graham Ruecroft and David Hipkiss and Tuan A. Ly and Neil Maxted and Peter W. Cains},
  journal={Organic Process Research \& Development},
  year={2005},
  volume={9},
  pages={923-932}
}

• G. Ruecroft, David Hipkiss, +2 authors P. W. Cains
• Published 17 September 2005
• Materials Science
• Organic Process Research & Development

An overview of the application of power ultrasound to crystallization of organic molecules, and the equipment developed in recent years in which sonocrystallization and sonochemistry may be carried out at industrial scale, is presented. It includes both results from the research and development programs carried out by us and a survey of developments in the field more generally. The most important effect of ultrasound on crystallization is the induction of nucleation and the principal benefits derived from an ability to manipulate this effect. The reported effects of ultrasound on crystal nucleation and growth have been briefly reviewed, and examples are given of physical properties of the products having been manipulated by varying and controlling the insonation regime. New applications, directions, and developments have been identified. Developments in scale-up methods and available equipment have also been reviewed. It is the availability of robust large-scale equipment that has been critical to establi...