Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-Cell lymphoma

@article{Kim2009SonicHS,
  title={Sonic hedgehog signaling proteins and ATP-binding cassette G2 are aberrantly expressed in diffuse large B-Cell lymphoma},
  author={Ji Eun Kim and Rajesh Ramachandra Singh and J H Cho-Vega and Elias Drakos and Yogesh Davuluri and Faisal A Khokhar and Luis E. Fayad and L Jeffrey Medeiros and Francisco de la Vega},
  journal={Modern Pathology},
  year={2009},
  volume={22},
  pages={1312-1320}
}
Dysregulation of the sonic hedgehog (SHH) signaling pathway has been shown in several cancer types, but has not been explored in diffuse large B-cell lymphoma. We assessed 67 cases of diffuse large B-cell lymphoma for expression of SHH (ligand), GLI1, GLI2 and GLI3 (transcriptional effectors of SHH signaling), and the ATP-binding cassette (ABC)G2 (a downstream target of SHH signaling), using immunohistochemistry. For comparison, we assessed the expression levels of these proteins in 28 cases of… CONTINUE READING
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