Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer.

@article{Chen2013SonicHS,
  title={Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer.},
  author={Jing-song Chen and Xiao-hui Huang and Qian Wang and Jiong-qiang Huang and Long-juan Zhang and Xi-Lin Chen and Jian Lei and Zhi-xiang Cheng},
  journal={Carcinogenesis},
  year={2013},
  volume={34 1},
  pages={10-9}
}
The aberrant activation of sonic hedgehog (SHH) pathway contributes to initiation and progression of various malignancies. However, the roles and underlying mechanisms of SHH signaling pathway in invasion and metastasis of liver cancer have not been well understood. In this study, we found that SHH signaling was activated and correlated with invasion and metastasis in hepatocellular carcinoma (HCC). Enhanced SHH signaling by recombinant human SHH N-terminal peptide (rSHH-N) promoted hepatoma… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 51 references

Targeting the Hedgehog pathway in cancer

Nature Reviews Drug Discovery • 2006
View 4 Excerpts
Highly Influenced

Activation of the hedgehog-signaling pathway in human cancer and the clinical implications

L Yang
Oncogene • 2010
View 1 Excerpt

FAK is involved in invasion and metastasis of hepatocellular carcinoma

Clinical & Experimental Metastasis • 2010
View 10 Excerpts

Involvement of PI3K/PTEN/AKT/mTOR pathway in invasion and metastasis in hepatocellular carcinoma: Association with MMP-9.

Hepatology research : the official journal of the Japan Society of Hepatology • 2009
View 10 Excerpts

Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer

J Bussink
Lancet Oncol., • 2008
View 1 Excerpt

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