Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells.

@article{Stewart2002SonicHS,
  title={Sonic hedgehog signaling modulates activation of and cytokine production by human peripheral CD4+ T cells.},
  author={Gareth A. Stewart and Jacqueline A. Lowrey and Sonia J. Wakelin and Paul M Fitch and Susannah Lindey and Margaret J. Dallman and Jonathan Robert Lamb and Sarah E. M. Howie},
  journal={Journal of immunology},
  year={2002},
  volume={169 10},
  pages={5451-7}
}
Sonic hedgehog (Shh) is important in the growth and differentiation of a variety of cell types, including the development of T cells in the thymus. This prompted us to investigate whether Shh signaling is a functional component of the physiological response of human mature CD4(+) T cells following Ag recognition. In this study, we demonstrate that Shh and its receptor Patched (Ptc) are expressed on resting and activated human peripheral CD4(+) T cells. In approximately one-half of the randomly… CONTINUE READING