Sonic hedgehog signaling is important in tooth root development.

  title={Sonic hedgehog signaling is important in tooth root development.},
  author={Mitsushiro Nakatomi and Ikuo Morita and Kazuhiro Eto and Masato S. Ota},
  journal={Journal of dental research},
  volume={85 5},
Hertwig's epithelial root sheath (HERS) is important for tooth root formation, but the molecular basis for the signaling of root development remains uncertain. We hypothesized that Sonic hedgehog (Shh) signaling is involved in the HERS function, because it mediates epithelial-mesenchymal interactions during embryonic odontogenesis. We examined the gene expression patterns of Shh signaling in murine developing molar roots. Shh and Patched2 transcripts were identified in the HERS, whereas… CONTINUE READING